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From: Dr. Geno Marcovici
Date: 12/3/2001
Time: 12:19:16 AM
Remote Name: 172.156.178.194
The advent of topically delivered minoxidil (Rogaine) in the early to mid 1980's demonstrated for the first time that pharmacological treatment of pattern hair loss was a viable option. In the early 1990's the development of orally administered finasteride (Propecia) showed that a systemically focused 5AR (5-alpha reductase) blockade was also a realistic target for the purpose of arresting hair loss. Importantly, this drug established a basis for the systemic use of a 5AR inhibitor against pattern hair loss. You may recall that 5AR has been strongly implicated in precipitating the hormonal processes linked to pattern hair loss also known as androgenetic alopecia (AGA).
The next evolutionary step in this process was our recognition that botanically derived molecules may offer a number of compelling advantages over pharmaceutically based alternatives. In fact, we were the first to offer botanically based hair loss treatment formulations beginning in 1996. In the past several years a great deal of research has been directed toward the examination of a number of naturally educed substances, specifically those which have shown the ability to inhibit 5AR. The most widely researched substance of this kind is the liposterolic extract of saw palmetto (LSESr). Historically, this botanical earned an excellent track record of success against BPH (benign prostatic hyperplasia), a prostate disorder linked with the same metabolic changes evident in AGA.
Noted researchers tested this substance against pharmaceutical compounds such as minoxidil and finasteride. They found that it compared very favorably in a number of relevant lab assays, particularly those involving the inhibition of 5AR. In one research study it was shown that LSESr was a 3-fold more efficient inhibitor of this problematic enzyme than the drug finasteride.
Recently, newly recognized botanicals such as grape seed extract, borage oil, evening primrose oil, and others, have also shown promising activity against the changes associated with AGA. It is our hypothesis that a number of these botanical tools may offer greater efficacy when combined together, in contrast to any one substance utilized alone.
In our laboratory, we have advanced this early research in several ways. Now, we have developed a new generation of oral and topical formulas based heavily around these novel extracts. Further, we have examined one new generation formula in a placebo-controlled, double-blind clinical trial. A manuscript detailing results from this study has been submitted for publication within a peer-reviewed scientific journal and is currently under editorial review. We continue to examine novel botanical molecules in an effort to harness them as new weapons against AGA.
Botanicals offer a powerful set of tools in the treatment of pattern hair loss. In the coming years ahead, we may anticipate the development of ever more efficacious treatment options based on this paradigm. Our goal is to continue to provide our valued clients with the most scientifically advanced product line to combat hair loss.
Dr. Geno Marcovici Chief Scientific Officer HairGenesis dr.marcovici@hairgenesis.com
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