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Re: to sOuL and Pants re RU58841

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From: wwf divas naked
Date: 05 Jun 2008
Time: 09:25:14
Remote Name: 203.162.2.135

Comments

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From: sOuL (to Pete and Pants)
Date: 11/26/2001
Time: 8:06:12 PM
Remote Name: 64.230.216.101

Comments

Sounds great Pete!

Can't wait to see that letter!

Here is a recent study on RU, you may want to inlcude it...

>>>RU 56187 and RU 58841.

New antiandrogen with nonsteroid structure. They are N-substituted arylthiohydantoins.

Mechanism: Inhibit 5 alpha-dihydrotestosterone (5-alpha-DHT) and testosterone receptors activity by blocking androgen receptors . RU 58841 and RU 56187 are eliminated from blood stream relativelly quickly, but they form a common metabolite, the N-desalkyl derivative, RU 56279 (also antiandrogen), which is eliminated much more slowly and is responsible for general adverse antiandrogenic effects. But, % of RU 58841 transformation into RU 56279 is very low (1%). Therefore, if applied topically, it has prominent local effect and untraceable general effects. Clinical studies of RU58841 on topical application in Department of Pathology, University of Rochester Medical Center, revealed a potent increase in density, thickening, and length of hair in the macaque model of androgenetic alopecia.

Very powerful new receptor inhibitors. Their affinity for androgen receptors is three times higher than the affinity of testosterone. One of them, RU 58841can be used topically. It is probably one of the most promissing new drugs.>>>

I am extremly curious as to what Dr. Lee may want to do???

Keep us informed Pete...

Regards,

sOuL

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