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From: Newbie Pete
Date: 3/12/2002
Time: 11:48:25 AM
Remote Name: 195.93.32.156
Hi,
Checkout the hyperlink as the first point of any hair re growth regime is to establish your hormone levels.
Pete :)
March 6, 2000
Some new information from a just concluded study may clarify how DHT affects hair loss and how Propecia (Finasteride) helps to stop hair loss and regrow hair.
Dr. Marty Sawaya and Dr. Maria Hordinsky recently completed a study on the effects of finasteride that showed some interesting results. They discussed their results during a lecture at the World Hair Society meeting last week in Orlando, Florida.
"Some of the work we've recently done in a Merck education grant was to look at cell death factors in apoptosis, but we also looked at the A and B forms of the androgen receptor and found that this is switching with finasteride treatment," said Dr. Sawaya.
Androgens are male hormones and androgen receptors are the cell structures that the hormones bind to in the cells to cause different hormonal effects in the body, such as the stimulation or inhibition of hair growth. Recent studies (see study below) have shown that there is more than one type of androgen receptor, an A form and a B form. Different receptor forms can have different activities when binding with the same hormone, so it is possible that the A form of the androgen receptor causes hair growth inhibition when it predominates in a follicle, while the B form promotes normal growth.
"Two forms of the receptor exist..." reported Dr. Sawaya, "The B form is thought to predominate and about 80% is expressed in normal cells while the A form is about 20% of the expressed form of the androgen receptor. We find that in male pattern hair loss, those men affected with hair loss, there's more of a switch to the A form rather than the B form which should be there. So maybe the A form is signalling some sort 'alopecia' aspect verses the B form being the good one."
Hairs in the back of the scalp have a normal ratio of A and B androgen receptors, while Dr. Sawaya's report shows that hairs on the top of the scalp in balding men have more A receptors than B receptors. Dr. Sawaya's recent study showed that with the use of Finasteride, androgen receptors are switching back to the B form. This may further expand our knowledge of how DHT causes hair loss and how Finasteride prevents further loss and regrows hair.
In further news on Propecia, Dr. Sawaya and Dr. Hordinsky also stated that Merck is expected to release the final results of the 5 year study on Propecia at next weeks American Academy of Dermatology (AAD) meeting. Regrowth.com will be covering the AAD meeting and will be reporting any results presented.
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