Re: Message for Trey Re: EPM

From: Moonlighting
Date: 6/22/2002
Time: 9:03:54 PM
Remote Name: 148.233.95.58

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Well i think they will work out to find out something that is going to offer a better topical against hairloss but I found this on Keratin.com, it seems that the japanesses have been working on this before.... (this was at the discussion forum, Androgenetic Alopecia on a post that is called ptential baldness cures on the way!)

Reading the page it seems as though they are working on Epimorphin. This is a factor that is involved in hair follicles morphogenesis that we have known about for a while (some abstracts below). Much of the work on epimorphin was done in Japan and it would seem Sumitomo have taken it on as a commerical project.

Thier web page leaves something to be desired in terms of its explanation of the project, but it seems that applying epimorphin to adult mice stimulates anagen in telogen follicles and applying it to embryos accelerates hair follicle development - though I didn't see anything that convinced me that new hair follicles were formed.

It is reasonable that epimorphin would stimulate hair follicle growth - so do several other factors. The main question will be whether it stimulates other things to grow that you don't want (ie tumors).

Given that most of mouse hair follicles are in telogen (in contrast to humans where most hair folicles are in anagen) the effects in humans are going to be less clear cut than their mouse studies. Obviously the company will have to do some human clinical trials to see how much growth epimorphin stimulates in AGA affected hair follicles.

Br J Dermatol 1999 Sep;141(3):447-52 Epimorphin expression during human foetal hair follicle development. Akiyama M, Amagai M, Smith LT, Hashimoto K, Shimizu H, Nishikawa T. Division of Dermatology, Kitasato Institute Hospital, Tokyo 108-8642, Japan.

Epimorphin is a mesenchymal protein expressed in several organs and known to have an essential role in epithelial tissue organization, including hair follicle morphogenesis, in mice. Although about 90% homology has been reported between human and mouse epimorphin exon sequences, there is no information about expression and function of epimorphin in hair follicle development in humans. In order to elucidate the expression pattern of epimorphin in human hair follicle morphogenesis and to compare it with the distribution of tenascin and neural cell adhesion molecule (NCAM), skin samples from human foetuses of a series of estimated gestational ages (EGAs) (46-168 days EGA) were studied using monoclonal anti-epimorphin antibody MC-1, anti-tenascin antibody and anti-human NCAM antibody. Epimorphin was detected in the mesenchymal cell condensation at the pregerm stage ( 134 days EGA), dermal papilla cells expressed epimorphin as well as tenascin and NCAM. These results indicate that epimorphin expression is closely linked to developing hair follicles in human foetuses. This suggests that epimorphin may have an important part in induction of morphogenesis during human foetal hair follicle development.

J Dermatol Sci 1996 Dec;13(3):193-201 Immunolocalization of epimorphin in skin. Butt KI, Manabe M, Yaguchi H, Tsuboi R, Ogawa H. Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan.

Epimorphin was originally identified as a mesenchymal cell surface-associated protein that modulates epithelial morphogenesis in embryonic skin and lung epithelia. A previous report which utilized embryonic mouse skin, showed that epimorphin was localized non-homogeneously in a region adjacent to the epidermis and in a mesenchymal cell condensation located in front of growing hair follicles. We report herein a further detailed localization of this protein in adult mouse skin using immunoelectron microscopy. Epimorphin was found to be localized on the undersurface of basal cells, in the cytoplasm of cell processes of fibroblasts, as well as on the plasma membrane of fibroblasts, endothelial cells, pericytes, perineurium and endomysium. Our present finding indicated that epimorphin is one of the factors involved in multiple biological functions in a variety of structures derived from various origins and that it is not a specific epithelial morphogenetic factor.

Cell 1992 May 1;69(3):471-81 Epimorphin: a mesenchymal protein essential for epithelial morphogenesis. Hirai Y, Takebe K, Takashina M, Kobayashi S, Takeichi M. Biomaterial Research Institute, Yokohama, Japan.

A novel 150 kd protein expressed on the surface of mesenchymal cells of mouse embryonic tissues was identified. A monoclonal antibody to this molecule inhibited various processes of epithelial morphogenesis, such as hair follicle growth and lung epithelial tubular formation, in organ cultures of these tissues. Sequence analysis of cDNA encoding this protein revealed that it had 289 amino acids with a hydrophobic stretch at the C-terminus. NIH 3T3 cells transfected with the cDNA of this protein expressed the exogenous 150 kd protein on their surface. When lung epithelial cells were cocultured with these transfected cells, they showed normal tubular morphogenesis, but not with untransfected NIH 3T3 cells. These results indicate that this protein, termed epimorphin, plays a central role in epithelial-mesenchymal interactions.

vaniqa

From: vaniqa
Date: 19 Sep 2007
Time: 04:03:19
Remote Name: 76.67.196.109

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From: land
Date: 29 Jul 2008
Time: 09:32:59
Remote Name: 218.26.219.186

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From: giasznht
Date: 25 Aug 2008
Time: 01:43:16
Remote Name: 70.112.245.35

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