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Farrell
Hair Replacement - Voted # 1 In The World For 5 Consecutive Years ! |
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From: S Foote.
Date: 6/22/2002
Time: 10:21:01 AM
Remote Name: 195.93.48.164
I think the reference to the status of pseudohermaphrodites in this thread, raises an interesting question?
As i understand it, these individuals lack the type II isozyme that converts T to DHT, but retain the type I isozyme? Type I doesn't exist within hair follicle cells, only type II.
If as stated, pseudohermaphrodites start to bald when given testosterone, this would demonstrate an indirect effect of DHT in the balding proccess, and not a direct action as currently thought!
There is no type II isozyme in hair follicle cells to convert this extra testosterone into DHT in these individuals? Thus the increased levels of DHT produced externally by the type I isozyme, must be making the difference here? If it is going to be argued that more DHT is penetrating the hair follicle cells from the circulation, this would mean a natural DHT resistence in MPB suseptible follicles of at least 30%, the relative amount normally produced by the type I isozyme?
If this is the case, Finasteride should work a lot better than it does!
S Foote.
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