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Topic 580 - GlaxoSmithKline Dutasteride (Avolve / Duagen) Hair Loss Discussion Group - forum 25

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Re: The Importance of DHT Reduction--I stand by my position

From: Bryan to Stephen Foote
Date: 6/22/2002
Time: 1:20:53 PM
Remote Name: 209.144.226.181

Comments

>>As i understand it, these individuals lack the type II isozyme that converts T to DHT, but retain the type I isozyme?<<

That is correct.

>>Type I doesn't exist within hair follicle cells, only type II.<<

That is NOT correct. Both types exist within the hair follicle.

>>If as stated, pseudohermaphrodites start to bald when given testosterone, this would demonstrate an indirect effect of DHT in the balding proccess, and not a direct action as currently thought!<<

I'm still waiting to hear a reference for that claim about giving testosterone to pseudohermaphrodites; however, even if it's true, it still doesn't really establish anything about whether DHT's effect is direct or indirect, because both types of the 5a-R enzyme exist within the hair follicle.

Bryan

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