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Topic 580 - GlaxoSmithKline Dutasteride (Avolve / Duagen) Hair Loss Discussion Group - forum 25

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Re: The Importance of DHT Reduction--I stand by my position, to Schmoe and Bryan

From: Common Sense
Date: 6/22/2002
Time: 4:10:39 PM
Remote Name: 63.204.74.131

Comments

Bryan, Your postings have long left me with the impression that you are way down on anti-androgen approaches. Just yesterday, 6/22, I stated "Going after the binding or manufacture of testosterone metabolites is where it's (research) at for now." You replied "Naw, I tend to agree with the previous poster (who said androgens is not where it's at). The antiandrogenic approach seems to get you only so far."

Bryan, ALL current approaches only get you so far! But, again, the ones that predominately go after curbing androgens are far more likely to be worth salt. And I will give you some other unsolicited advice. You say you desire to use topicals. I would like to share with all readers that while we would all prefer a topical over an oral for safety reasons, keep in mind that to be effective the drug must be delivered to the deepest parts of the skin, and 100% protect the follicles that reside there from the androgenic effects 100% of the time! You can see where your topical minoxadil or fatty acids fall far short. An excellent approach SUPPORTED IN THEORY AND BY TONS OF RESEARCH might be, for example, oral Dutasteride (to significantly knock down DHT) along with topical RU58841 delivered by liposomes (to help neutralize any remaining DHT).

To answer Schmoe's questions, yes, I tried Ru58841 on 3 balding men. It stopped the frontal hairloss, but unsurprisingly, did not grow back much hair (can't wait to try it with Dut, tho). As to your question about reviving hairs after DHT neutralization, it will vary amongst individuals for many reasons. One factor affecting regrowth, for example, would be the degree of fibrosis (scarring) that has occcured from any inflamation (a secondary effect of androgens in some genetically predisposed to baldness, and requiring the presence of androgens). Again, we need a treatment that wipes out DHT (or blocks androgen effects in other ways) as much as possible to halt the process, then we can all see what may come back spontaneously as well as what may be encouraged via trial and error with other products (maybe then I will change my position and agree that it is worthwhile to try such things as Dr. Proctor's products that work topically and in different theoretical ways).


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