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Topic 580 - GlaxoSmithKline Dutasteride (Avolve / Duagen) Hair Loss Discussion Group - forum 25

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Re: HI DRIPPPPPING  sweat from balding areas ?? coincidencei...

From: S Foote.
Date: 6/22/2002
Time: 4:47:39 PM
Remote Name: 195.93.48.156

Comments

I'll try to sum up my hypothesis, as briefly as possible.

This arises from a simple hydraulic model that would be the easiest way (Ockhams Razor), to adjust hair growth in line with environmental temperature changes in evolving mammals. In this model, increased tissue fluid pressure around hair follicles, puts pressure on anagen follicle development, and restricts follicle enlargement through the natural force of contact inhibition. This reduces hair growth. Reduced tissue fluid pressure has the opposite effect, allowing `Space' for the natural enlargement of anagen follicles and increased hair growth.

The abstract of the study on DHT related hair growth and sweat secretion,strongly supports this hydraulic mechanism in MPB, as does the recognised effect on tissues of increased fluid levels (hair loss, immune sensitivity, and fibrosis). http://www.lymphoedema.org.au/lymphoed.htm I refer to other supporting evidence for this mechanism in MPB in my paper.

The implication of this in MPB, is that effective treatment will only be achived by reducing the fluid pressure in the scalp, to allow the natural enlargement of hair follicles.

S Foote.


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