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Topic 609: GlaxoSmithKline Avodart/Dutasteride - forum 31

Re: SO IF DUT SUPRESSES ALMOST ALL DHT BUT HAIRGROWTH IS JUST...

From: Bryan
Date: 10/22/2002
Time: 12:33:10 AM
Remote Name: 66.94.136.114

Comments

>>Calibus posted here a day or two ago that castrated males can still have up to 40% dht production.<<

More like 30%. I posted the citation earlier to the study that measured that in a large group of men.

>>I don't have the studies to corroborate this claim but I can say I've read that castration will cause the adrenal glands to upregulate the amount of dht in the body.<<

Ummm...I doubt that. In any event, the important point is that regardless of whether or not there's any "upregulation", castration STILL causes a dramatic decline in total androgenic stimulation. Serum DHT may drop by "only" 70% or so compared to the low 90's with dutasteride, but you have to remember the other factor: testosterone is dramatically reduced by 95% or so with castration, whereas dutasteride actually RAISES it a little! When you factor that into the androgenic equation, there's not much difference between the two.

Bryan