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From: S Foote.
Date: 10/22/2002
Time: 3:21:58 PM
Remote Name: 195.93.34.8
There is a point about the in vitro studies of androgen response of balding and non balding follicles that i have made to Bryan before.
It is said that balding and non balding follicles respond differently to androgens in vitro, and this `PROVES' that the follicles must be inherently `different'. IE, hair follicles are genetically pre-programed to respond to rising levels of DHT at puberty, from birth? Am i the only person who see's a problem with this in vitro testing?
It is agreed that rising levels of DHT are involved in the MPB process. The question is, is this a direct effect or an indirect effect? An indirect effect on follicle size could occur through DHT induced changes in the tissue around hair follicles? The quoted in vitro testing of balding and non balding follicles, does not answer this question!
The quoted in vitro testing uses follicle samples that are already different!! The balding samples have ALREADY been altered by an in vivo process! These samples are contaminated! The in vivo alteration could be either a direct or indirect effect of DHT? Of course the `already different' samples are going to react differently to subsiquent `in vitro' exposure to androgens! They will probably react differently to a host of other substances in vitro!
The only way to CONCLUSIVELY prove that hair follicles are genetically pre-programed FROM BIRTH to respond differently to rising levels of DHT at puberty, is to test samples from young boys! Before Rising levels of DHT have had a chance to influence hair follicles either directly or indirectly in vivo!!
According to the prevailing theory of genetically different follicles, some of the samples from the MPB area should respond differently to androgens in vitro. These samples will be from young boys who are `predisposed' to MPB in later life, right?
The problem is that as far as i know, this testing has not been done, and untill it is the genetic difference theory is just that, a `theory'.
In my opinion, the poor regrowth capability of drugs that reduce DHT reported here, indicate that DHT does NOT effect hair follicles directly.
S Foote.
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