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Topic 609: GlaxoSmithKline Avodart/Dutasteride - forum 31

Re: SO IF DUT SUPRESSES ALMOST ALL DHT BUT HAIRGROWTH IS JUST...

From: Bryan to the anonymous fellow...
Date: 10/22/2002
Time: 4:44:46 PM
Remote Name: 207.136.39.194

Comments

>>Yes thank you for school a pity mortal such as much self if the ways of study interpretation.<<

Hey, it looks like you could use some schooling in proper grammar and spelling, too!

Sorry for that, but if you're going to flame ME, then I reserve the right to send a little zinger YOUR way, too! :-)

>>Anyway, The Adrenal glands can increase their output of dht, especially under stress. What more stress can you put your body through than ripping out your testes?<<

First of all, the adrenal gland doesn't produce DHT. It produces weaker androgens like dehydroepiandrosterone and androstenedione. Those may be converted to testosterone in other tissues, and perhaps eventually to DHT.

Second of all, where did you get the idea that those weak androgens can increase, "especially under stress"? Are you confusing those androgens with other hormones like cortisol? ;-) As far as I can tell, there is no feedback mechanism for androgens as far as the adrenal gland is concerned; for instance, I can't find anything about LH having a stimulating effect on it, which would seem to be the most obvious way that it would work. If you know otherwise, then please cite a reference for that claim. I'll be happy to read all about it.

And don't forget this key statement that James Hamilton made in his study of castrates and hairloss: "These studies of eunuchs indicate that, even in the absence of testicular secretions and of any detectable increase in androgens from extratesticular sources, regrowth of coarse hairs on the frontal hairline is nil if the hairs have been lost when the subject was young". Did you get that? There was no detectable increase in "extratesticular androgens".

>>Furthermore, this only rings true if you believe testosterone is bad for hair. I really don't put much credence in in vitro studies.<<

Is that because they contradict your theories?

>>If you are willing to advocate the testosterone hair apoptosis studies then you must be a big proponent of azealic acid also. Yet I don't hear you citing that study too often. It seems to me you have selective study citing syndrome.<<

Sonny, I've already thoroughly explained my position on azelaic acid and its problems. I'm not going to rehash it here again. See my past postings on it.

Bryan