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Topic 609: GlaxoSmithKline Avodart/Dutasteride - forum 31

Re: SO IF DUT SUPRESSES ALMOST ALL DHT BUT HAIRGROWTH IS JUST...

From: The Ghost of Dr. Hamilton
Date: 10/22/2002
Time: 8:32:41 PM
Remote Name: 165.247.16.110

Comments

> The only way to CONCLUSIVELY prove that hair follicles are > genetically pre-programed FROM BIRTH to respond differently to rising > levels of DHT at puberty, is to test samples from young boys! Before > Rising levels of DHT have had a chance to influence hair follicles either > directly or indirectly in vivo!!

One way in which genetics affects MPB is by increased activity of certain steroid enyzmes in the hair follicle. This is not by chance....................

J Invest Dermatol 2001 Jan;116(1):57-61 Related Articles, Links

Biochemical roles of testosterone and epitestosterone to 5 alpha-reductase as indicators of male-pattern baldness.

Choi MH, Yoo YS, Chung BC.

Bioanalysis and Biotransformation Research Center, KIST, Seoul, Korea.

In establishing a theory to predict male-pattern baldness, we investigated the correlation of testosterone, epitestosterone, and dihydrotestosterone with 5alpha-reductase in hair using gas chromatography-mass spectrometry. One hundred milligram hair samples were obtained from a group of balding subjects and their sons, as well as from a corresponding aged-matched, nonbalding group. The ratio of testosterone to epitestosterone was significantly greater (mean 46.41, p < 0.001; mean 35.83, p < 0.001, respectively) in the hair of balding fathers (n = 19, age 28-50 y) and their sons (n = 16, age 8-16 y) than in the hair of the nonbalding control subjects (mean 9.17 and 10.47, respectively). These findings demonstrate that analysis of terminal hair may not only provide a basis for predicting baldness when the subject is still young, but also for preventing and treating male-pattern baldness by controlling the steroid hormone balance.

PMID: 11168798 [PubMed - indexed for MEDLINE]