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From: S Foote to Bryan.
Date: 10/24/2002
Time: 2:57:53 PM
Remote Name: 195.93.50.11
I am begining to wonder if you are deliberately playing `dumb' Bryan?
OK, just one more time.
>>Oh come on, Stephen, you're playing stupid word games!! You claim they are "contaminated", now I'm asking you what they are contaminated WITH!! ALL hair follicles are exposed to DHT! As usual, you're being evasive, because you have no answer to the 'in vitro' results. <<
Listen up Bryan.
We all agree that rising levels of DHT `triggers' a proccess of miniaturization in some scalp follicles, the question is, is this a direct effect of DHT on follicle cells or an indirect effect of DHT. For example, could DHT create different conditions in the tissue around follicles that effects the anagen enlargement proccess resulting in enlargement of follicles in some areas, and shrinkage of follicles in other areas? An `opposite' effect of DHT on hair follicles is accepted, why not therefore an opposte effect of DHT on the tissues around these follicles?
Because balding and non balding follicles react differently to DHT in vitro, you believe that this PROVES that MPB is due to a DIRECT effect of DHT on follicle cells. Would that be a fair summary of your opinion Bryan?
The balding samples used in the testing you quote are `contaminated' in that they have already been exposed to rising levels of DHT in vivo. DHT has already created a growth restricting chemistry in these samples, either directly, or possibly indirectly? They are now physically different from the other samples they are being compared with! The subsiquent different reaction to androgens, or any other substance in vitro, is meaningless!! It is like chemically comparing samples of a plant species that have been grown in completely different soils, and concluding that their different characteristics are due to `genetic differences' in the samples!!
If you REALLY want to properly test if rising levels of DHT DIRECTLY effects follicles in different ways, you have to use DHT `naive' follicle samples that COULD NOT have been previously subjected to any possible INDIRECT EFFECT of DHT IN VIVO!!. If these DHT naive samples then STILL react differently to introduced DHT in vitro, you have proved your case Bryan! Untill such testing is performed, the DIRECT effect of DHT on follicles you think is proven, is just a theory! This is an important point as all current hair loss research is based upon this `assumption'! Where has this taken us in the last 60 years since this assumption was made? Where are the effective treatments?
If you still don't understand the point i am making Bryan, there is no point continuing with this discussion.
S Foote.
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