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From: Bryan
Date: 10/24/2002
Time: 8:10:15 PM
Remote Name: 66.94.134.110
>>There is no "Hypothalamic-Pituitary-testicular" axis.<<
Of course there is!
>>The HPT axis is the Hypothalamic-Pituitary Thyroid axis.<<
But I didn't *say* "HPT". I spelled it out in full, hypothalamic-pituitary-testicular axis, so there was no possibility of misunderstanding it.
>>What you are referring to is the Hypothalamic-Pituitary-Gonad Axis (HPG). Sorry, I don't know who started using that phrase (and yes, I've seen it too) but it is incorrect and a pet peeve of mine.<<
It's a pet peeve of yours and you think it's incorrect when someone substitutes "testicle" for "gonad"? Are you serious?
>>Anyway, negative feedback in the HPG axis, much like the HPA and HPT axis, functions in most cases with timing similar to circadian rhythms. In other words, what you are talking about are the daily hormone level fluctuations (short loop negative feedback).
I'm not sure what you mean. Of course there will be circadian rhythms superimposed on the "average" levels of LH, but LH still determines the extent of testosterone production in the testes.
>>I am talking about TOTAL suppression of both DHT and Estrogen. Yes, this would result in a SHORT-TERM increase in testosterone, but would eventually cause the gonads to stop producing Luteinizing hormone.
Huh?? Luteinizing hormone is produced by the PITUITARY, not the gonads! It signals the testes to produce testosterone. And suppressing both estrogen and DHT would cause large increases in LH, with subsequent increases in testosterone production.
>>This would result in lowered levels of tesosterone for a long period of time. Eventually, Test levels would rise again and go through the same process, but not in one day. The point is that this long term fluctuation would cause problems on a grand scale, mostly when LH and FSH production are low. Just because estrogen and DHT levels would be nearly non-existent doesn't mean the body would produce more testosterone indefinitely. What you are referring to is the body trying to remain in balance. I am referring to a state where balance isn't possible.<<
I don't know where you got all of that. I think testosterone is a direct function of LH levels, and it WOULD produce more of it indefinitely, as long as LH stays high. I challenge you to find a reference to the contrary.
In any event, my main point was that estrogen and DHT are in fact players in the negative-feedback system for testosterone production, and I assume that you accept that now.
Bryan
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