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From: Bryan to Stephen Foote
Date: 10/26/2002
Time: 5:31:14 PM
Remote Name: 66.94.133.222
>>Listen up Bryan.
I'm listening, Stephen.
>>We all agree that rising levels of DHT `triggers' a proccess of miniaturization in some scalp follicles, the question is, is this a direct effect of DHT on follicle cells or an indirect effect of DHT. For example, could DHT create different conditions in the tissue around follicles that effects the anagen enlargement proccess resulting in enlargement of follicles in some areas, and shrinkage of follicles in other areas? An `opposite' effect of DHT on hair follicles is accepted, why not therefore an opposte effect of DHT on the tissues around these follicles?<<
Maybe about 50 years ago, that WOULD have seemed like reasonable speculation about the etiology of MPB, but now everything along those lines has been thoroughly discredited.
>>Because balding and non balding follicles react differently to DHT in vitro, you believe that this PROVES that MPB is due to a DIRECT effect of DHT on follicle cells. Would that be a fair summary of your opinion Bryan?<<
Oh, that's only part of it, Stephen. Other key points are that when you transplant individual hair follicles from one area of the scalp to another (like balding to non-balding, or non-balding to balding), the results are always the same: the transplanted follicle maintains its original characteristics wherever you put it. And applying topical antiandrogens that lack systemic effects is effective against balding. Those three facts neatly dispense with your theory.
>>The balding samples used in the testing you quote are `contaminated' in that they have already been exposed to rising levels of DHT in vivo. DHT has already created a growth restricting chemistry in these samples, either directly, or possibly indirectly? They are now physically different from the other samples they are being compared with! The subsiquent different reaction to androgens, or any other substance in vitro, is meaningless!! It is like chemically comparing samples of a plant species that have been grown in completely different soils, and concluding that their different characteristics are due to `genetic differences' in the samples!!<<
So how come hair follicles that are grown in different "soil" continue to do just fine when they are transplanted into the BAD "soil"?
>>If you REALLY want to properly test if rising levels of DHT DIRECTLY effects follicles in different ways, you have to use DHT `naive' follicle samples that COULD NOT have been previously subjected to any possible INDIRECT EFFECT of DHT IN VIVO!!. If these DHT naive samples then STILL react differently to introduced DHT in vitro, you have proved your case Bryan! Untill such testing is performed, the DIRECT effect of DHT on follicles you think is proven, is just a theory!<<
Sorry, Stephen, but first YOU have to provide answers to the points above which dismantle your theory.
Bryan
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