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From: TriedItAll
Date: 10/26/2002
Time: 7:21:16 PM
Remote Name: 63.57.247.174
A) I didn't say I think it is incorrect when someone substitutes testicle for gonad or vice/versa in general conversation, nor that it is my pet peeve. I said that it is incorrect to use the phrase Hypothalamic-Pituitary-Testicular axis. You see, the original (and correct) term, Hypothalamic-Pituitary-Gonad axis should be used because after the abstract and introduction in a study in which the authors first spell out Hypothalamic-Pituitary-Testicular axis, they will undoubtedly use the initials HPT for later reference. This is incorrect as HPT stands for Hypothalamic-Pituitary-Thyroid axis. The reason THAT is a pet peeve of mine is because my job involves the research of published studies in the field of endocrinology. I have seen the phrase used many times, even published in journals, but that doesn't make it right. I was only trying to educate you on the proper terminology. B) I NEVER stated that LH doesn't determine the level of testosterone produced in the testes. If you "don't understand what I mean", then perhaps you should research the difference between short loop and long loop negative feedback. It is basically the reason why excess test levels will reduce the production of LH in the long run. C) You claim to be knowledgeable about the subject of LH production, and then actually think you need to tell me that LH isn't produced in the testes. By "gonads" in my sentence, I am referring to gonadotrophs, which are the cells in the anterior pituitary that produce LH. Had I been writing that reply to the young man whose questions started this ball rolling, I wouldn't have abbreviated. For that matter, I would have simply said they were produced by basophilic cells. I will stop assuming that you know what I am referring to. D) So, you think the body would produce high levels of test indefinitely with total DHT and Estrogen inhibition? A two second search on Google revealed this link: www.neurosci.pharm.utoledo.edu/MBC3320/Androgens.htm. I'm sure with about ten minutes more time, or access to an online medical library such as the one I use at my job, I could find a large body of work that illustrates the process of Long-loop negative feedback. This biological occurence happens when too much testosterone is present whether the test is introduced to the body extraneously or through hormone manipulation such as total DHT and Estrogen suppression. E) I also NEVER stated that DHT and Estrogen aren't "players in the negative feedback system". I only stated that the total inhibition of both would actually raise testosterone levels enough to lower the production of LH in the LONG RUN, and consequently, the production of testosterone. Finally, let me say that I have no interest in going tit for tat with you about advice I give to people who ask for it, although I am perfectly willing to further embarrass you if you require it.
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