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Topic 609: GlaxoSmithKline Avodart/Dutasteride - forum 31

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Re: TRIEDITALL pls read

From: TriedItAll
Date: 10/27/2002
Time: 10:38:02 AM
Remote Name: 63.57.247.135

Comments

A) What do you think general conversation means? "Hey Bob, how are the wife and kids? Still manipulating your Hypothalamic-Pituitary-Testicular axis? Sure, I'll be there for the game on Sunday. You want me to bring anything?" The "general" in general conversation means "broad but not thorough" according to the American Heritage dictionary. I'll be damned if I am going to be anything BUT thorough when discussing technical terms, especially in a forum made for the discussion of medications.

B) I think it is "silly" to think you have nothing to learn. I am certainly not beyond correction, it just so happens that in this case I am absolutely correct. Which brings me to point...

C)So, HPG isn't the proper terminology, eh? Do yourself a favor, type "HPT axis" into google, one of the largest search engine on the net. Now, how many of the HPT references on that first several pages are for Hypothalamic-Pituitary-Testicular axis? A BIG FAT NONE OF THEM! Know why? For exactly the reason I stated, the "T" in HPT stands for Thyroid. Hopefully you won't ever do any research on the HPG axis as you will undoubtedly call it the Hypothalamic-Pituitary-Testicular axis. Then you will have to write it out EVERY SINGLE TIME or you will be WRONG! Say, captain wiseass, how can it be incorrect terminology in this instance but not when you say it. It seems YOU are trying to "set the standard for the entire medical field." But, hey...who am I to give you advice. You want to go on being wrong, knock yourself out.

D) DHT is produced by testosterone and estrogen is produced by testosterone and its precursors, yet the HPG axis is more responsive to DHT and estrogen than testosterone? What you talkin' bout, Willis?

E) Gall, huh... Are you suprised that I abbreviate? Isn't that what the above argument is all about? Oh, I forgot, you like spelling things out. OK, LH is produced in the gonadotrophs,and yes I did REALLY mean gonadotrophs. Sometimes when responding to people that are blatantly trying to pick a fight (I notice your not very popular around here) I get in a hurry. Fine, I'll accept that one, I should have spelled out gonadotrophs to avoid confusion. See, I can admit when I am in error, you should try it sometime! ;-p

D) So, you didn't see anything in my link. Apparantly you are illiterate as well as annoying. Under the heading SIDE EFFECTS OF TESTERONE ANALOGS, it states, "men can obtain the anabolic effect of administered testosterone or its derivitives systemically, but the HIGH CONCENTRATIONS INHIBIT LH RELEASE FROM THE ANTERIOR PITUITARY." Whether you administer testosterone or increase it via total DHT and estrogen inhibition, high test levels will reduce LH production.

E) I NEVER said the negative feedback system wasn't responsive to testosterone derivitives, it is simply a fact that LH production will be reduced when test levels are considerably high over long periods of time. This will happen regardless of DHT and estrogen levels.

D) I understand what you are saying, in fact, you are preaching to the choir about the negative feedback system. I simply disagree with the statement that large increases in testosterone, produced by ANY mechanism will not result in reduced LH production. Now, must we continue to argue? I really don't care enough to respond to you anymore, so I will let you have the last word that I know you so desperately need. And by the way, Avodart WILL be more effective than castration. It has yet to be proven that other androgenous hormones (i.e. the increase in test from Dutasteride use) will have any effect on MPB in humans. By the way, MPB stands for Male Pattern Baldness, not Male Pattern Bryan. Have a nice day!

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