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From: Bryan
Date: 10/27/2002
Time: 2:44:23 PM
Remote Name: 66.94.132.84
>>D) DHT is produced by testosterone and estrogen is produced by testosterone and its precursors, yet the HPG axis is more responsive to DHT and estrogen than testosterone? What you talkin' bout, Willis?<<
I said, IF it's more responsive to DHT and estrogen. I don't know for sure if it is, but one thing we DO know is that it IS responsive to DHT and estrogen at least to some degree. You cannot ignore the possible effect of combined estrogen and DHT inhibition on the feedback mechanism. It may be quite significant.
It's definitely a huge factor in dogs...see: "Effect of Dual Inhibition of 5-Alpha-Reductase and Aromatase on Spontaneously Developed Canine Prostatic Hypertrophy", Suzuki et al, The Prostate 37:70-76 (1998). A combination of finasteride and arimidex caused a dramatic 7-fold increase in serum testosterone. And that was after 80 days! Do you think it was eventually going to go back to normal? ;-)
>>Sometimes when responding to people that are blatantly trying to pick a fight (I notice your not very popular around here) I get in a hurry.<<
Bullshit. My very first reply to you was completely in good faith, and ever since then you have tried to be as obnoxious as possible. My responses to you since then have still been relatively muted, but yours have not.
Why don't we BOTH try to keep this on a professional level? Thanks in advance for your cooperation!
>>D) I understand what you are saying, in fact, you are preaching to the choir about the negative feedback system. I simply disagree with the statement that large increases in testosterone, produced by ANY mechanism will not result in reduced LH production.<<
Well, I'd still be interested to know if you can provide a reference to any PROOF of that claim. And please don't simply cite another reference to some basic information about the negative-feedback loop; that's certainly not in doubt. What I want is some proof that a new "set-point" of testosterone production that comes about from the reduction of estrogen and DHT isn't permanent. I don't think there IS any such proof. I think that the new "set-point" is maintained indefinitely, as long as estrogen and DHT remain low. However, I'll believe what you say if you can prove otherwise...
Bryan
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