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From: Hardwo0d
Date: 11/11/2002
Time: 3:48:59 AM
Remote Name: 65.191.162.105
http://www.hairlosssucks.com/newsletter/72001/articles/article03.htm
Notice how she says that the study was a short pilot study and that the best results were probably not seen, which is exactly what Monahan said. Shelton pointed out that regrowth was only 50% better than finasteride and asked why she called it the WOW drug. Sawaya replied by saying that 50% get moderate to dense regrowth as opposed to less than 25% with finasteride. Dr. Monahan said that he went from about a NW 5 to about a NW 3 or 2 within 6 months and he said that he probably had not seen the full benefit of the drug. Dr Monahan also said that after 1 MONTH people were asking what he was doing. Let's not forget that he was on .5 mg's and not the 2.5mg that was floating around. Let's also not forget that the hair counts that were taken were from 6 MONTHS, not 1 or even 2 years. I still have not seen one person go from a NW 5 to a NW 4.5 on minoxidil alone, make that topical minoxidil, not oral. Alot of people here have realistic expectations for the drug, because they havent had anything this good, but I BELIEVE that it will be the WOW drug we have been waiting for. I am a Calibus supporter, but he is fighting an unfair battle. After the Phase III trials are done i'm sure he'll have all the weaponary he needs to fight in here.
POINTS:
Dutasteride had a trial that ran for 6 months but was shut down by Glaxo.
Dutasteride haircounts SHOULD be even higher at that 1 year mark as per Dr. Marty Sawaya
DHT binds to the hair shaft and causes the follicle to shrink producing a smaller, finer hair. I BELIEVE that finasteride is NOT AS POTENT AS DUTASTERIDE in removing DHT in the shaft and therefore has not effect on areas that have been balding the longest. 5aR1, I believe is what resides in this area and is a key point on why Dutasteride is better at reducing scalp DHT. However, the reduction of Serum DHT and the inhibition of the 5aR2 are also important, because they too cause bind to the follicle, this is why a 5aR1 inhibitor does not work by itself toward hairloss. Total DHT reduction is not achieved by castration and therefore is not an ideal way to treat hairloss. Its Serum DHT inhibition can be compared to that of Finasteride appx 60 - 70%. Moreover, since the serum DHT inhibition reached by Dutasteride is vastly superior to that of finasteride or castration; continuos use of the drug will lead to more regrowth over time. This is because the DHT that has binded to the follicle will slowly dissapate and allow for the follicle to prodcue a normal hair again. However, Scalp DHT cannot be compared with these drugs, becuase the results from a scalp biopsy trying to measure Scalp DHT are inconsistent. There are some studies that show Scalp DHT Inhibtion of finasteride at 70 and some that show it at ~20 and the same goes for Dutasteride. It is very hard to debate for Duasteride, because there only limited trial results that can be used in its defense. I think that for the vast majority this drug will work miracles and help stave off the wait for the next generation of hair restoration.
From: pwd
Date: 25 Jun 2006
Time: 03:31:21
Remote Name: 62.84.11.43
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